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ea0020p575 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effect of prolonged treatment with potassium canrenoate, a MR antagonist, on basal and stimulated hypothalamus–pituitary–adrenal (HPA) axis in humans

Berardelli Rita , Marinazzo Elisa , Prats Elisa , Picu Andreea , Giordano Roberta , Ghigo Ezio , Arvat Emanuela

HPA is negatively regulated by glucocorticoid feed-back at hypothalamic, pituitary and hippocampal level by glucocorticoid (GR) and mineralcorticoid (MR) receptors. MR antagonists impair HPA rhythm after acute administration. The aim of this study was to verify HPA activity and glico-insulinemic profile both basally and after acute administration of potassium canrenoate (CAN), before and after chronic treatment. We evaluated ACTH, cortisol (F) and dehydroepiandosterone (DHEA) ...

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Endocrine Abstracts

Effect of prolonged treatment with potassium canrenoate, a MR antagonist, on basal and stimulated hypothalamus–pituitary–adrenal (HPA) axis in humans

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